Malabsorption (post-gastrectomy, IBD, pancreatitis).chronic alcoholism, starvation/ anorexia, severe vomiting/ diarrhea, unbalanced TPN) ![]() Thiamine (vitamin B1) deficiency caused by.Brain lesions/atrophy usually occur in: mamillary bodies (nearly all cases), thalamus, periaqueductal gray matter, 3rd/4th ventricle, cerebellum, frontal lobe.Alterations in myelination leads to peripheral neuropathy.Lipid metabolism (including myelin sheath formation).Deficiency leads to lactic acidosis, altered brain metabolism.Energy production pathways (Kreb's cycle, pentose phosphate pathway, alpha-ketoglutarate dehydrogenase, pyruvate dehydrogenase).Only 20% identified before death, failure of diagnosis leads to 20% mortality and 75% permanent damage. ![]() ![]()
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